Neisseria meningitidis RTX proteins are not required for virulence in infant rats.
نویسندگان
چکیده
RTX cytotoxins play an important role in virulence of numerous gram-negative pathogens. Unexpectedly, however, we show here that the RTX proteins of Neisseria meningitidis are dispensable for virulence in the infant rat model of infection.
منابع مشابه
Unusual genetic organization of a functional type I protein secretion system in Neisseria meningitidis.
Proteins secreted by Neisseria meningitidis are thought to play important roles in the pathogenesis of meningococcal disease. These proteins include the iron-repressible repeat-in-toxin (RTX) exoprotein FrpC. Related proteins in other pathogens are secreted via a type I secretion system (TOSS), but such a system has not been demonstrated in N. meningitidis. An in silico search of the group B me...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 71 4 شماره
صفحات -
تاریخ انتشار 2003